CAS 107868-30-4 (email: firstname.lastname@example.org)
Product name: Exemestane
Alias: Aromasin ; Exemestan;Exemestane,Exemestane Aromasin
Product Category: Pharmaceutical raw materials and intermediates
CAS Registry Number:107868-30-4
Molecular formula: C20H24O2
Appearance: White or Almost White Crystalline Powder
Grade : Pharmaceutical Grade
Storage: Shading, confined preservation
Usage: Developed to help fight breast cancer, Aromasin is one of the most powerful estrogen suppressing compounds
Other drugs in same class: Anastrozole,Letrozole,Tamoxifen citrate,Exemestane
Exemestane is an oral steroidal aromatase inhibitor that is used in ER-positive breast cancer in addition to surgery and/or radiation in post-menopausal women.
The main source of estrogen is the ovaries in premenopausal women, while in post-menopausal women most of the body's estrogen is produced via the conversion of androgens into estrogen by the aromatase enzyme in the peripheral tissues (i.e. adipose tissue like that of the breast) and a number of sites in the brain. Estrogen is produced locally via the actions of the aromatase enzyme in these peripheral tissues where it acts locally. Any circulating estrogen in post-menopausal women as well as men is the result of estrogen escaping local metabolism and entering the circulatory system.
Exemestane is an irreversible, steroidal aromatase inactivator, structurally related to the natural substrate . It acts as a false substrate for the aromatase enzyme, and is processed to an intermediate that binds irreversibly to the active site of the enzyme causing its inactivation, an effect also known as "suicide inhibition." By being structurally similar to enzyme targets, Exemestane permanently binds to the enzymes, preventing them from converting androgen into estrogen.
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